Ontology highlight
ABSTRACT:
SUBMITTER: Kim DJ
PROVIDER: S-EPMC3643416 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Kim Dong Joon DJ Lee Mee-Hyun MH Reddy Kanamata K Li Yani Y Lim Do Young DY Xie Hua H Lee Sung-Young SY Yeom Young Il YI Bode Ann M AM Dong Zigang Z
Carcinogenesis 20130125 5
The mitogen-activated protein kinase kinase 1 and 2 signaling pathway is a major component of the RAS (Rat sarcoma)/RAF (Radpidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase kinase)/ERKs (Extracellular signal-regulated kinases) signaling axis that regulates tumorigenesis and cancer cell growth. MEK is frequently activated in various cancers that have mutations in the KRAS and BRAF oncogenes. Therefore, MEK has been suggested as a therapeutic target for inhibitor development a ...[more]