Ontology highlight
ABSTRACT:
SUBMITTER: Sharma A
PROVIDER: S-EPMC3643571 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Sharma Amit A Kottur Jithesh J Narayanan Naveen N Nair Deepak T DT
Nucleic acids research 20130321 9
The Y-family DNA polymerase IV or PolIV (Escherichia coli) is the founding member of the DinB family and is known to play an important role in stress-induced mutagenesis. We have determined four crystal structures of this enzyme in its pre-catalytic state in complex with substrate DNA presenting the four possible template nucleotides that are paired with the corresponding incoming nucleotide triphosphates. In all four structures, the Ser42 residue in the active site forms interactions with the b ...[more]