Ontology highlight
ABSTRACT:
SUBMITTER: Farina F
PROVIDER: S-EPMC3643607 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Farina Francesca F Pierobon Paolo P Delevoye Cédric C Monnet Jordan J Dingli Florent F Loew Damarys D Quanz Maria M Dutreix Marie M Cappello Giovanni G
Nucleic acids research 20130329 9
During the past years, exogenous DNA molecules have been used in gene and molecular therapy. At present, it is not known how these DNA molecules reach the cell nucleus. We used an in cell single-molecule approach to observe the motion of exogenous short DNA molecules in the cytoplasm of eukaryotic cells. Our observations suggest an active transport of the DNA along the cytoskeleton filaments. We used an in vitro motility assay, in which the motion of single-DNA molecules along cytoskeleton filam ...[more]