Ontology highlight
ABSTRACT:
SUBMITTER: Trinh DL
PROVIDER: S-EPMC3643765 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Trinh Diane L DL Scott David W DW Morin Ryan D RD Mendez-Lago Maria M An Jianghong J Jones Steven J M SJ Mungall Andrew J AJ Zhao Yongjun Y Schein Jacqueline J Steidl Christian C Connors Joseph M JM Gascoyne Randy D RD Marra Marco A MA
Blood 20130304 18
Diffuse large B-cell lymphoma (DLBCL) accounts for 30% to 40% of newly diagnosed lymphomas and has an overall cure rate of approximately 60%. Previously, we observed FOXO1 mutations in non-Hodgkin lymphoma patient samples. To explore the effects of FOXO1 mutations, we assessed FOXO1 status in 279 DLBCL patient samples and 22 DLBCL-derived cell lines. FOXO1 mutations were found in 8.6% (24/279) of DLBCL cases: 92.3% (24/26) of mutations were in the first exon, 46.2% (12/26) were recurrent mutatio ...[more]