Ontology highlight
ABSTRACT:
SUBMITTER: DeKelver RC
PROVIDER: S-EPMC3643768 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
DeKelver Russell C RC Yan Ming M Ahn Eun-Young EY Shia Wei-Jong WJ Speck Nancy A NA Zhang Dong-Er DE
Blood 20130220 18
AML1-ETO (RUNX1-ETO) fusion proteins are generated by the 8;21 translocation, commonly found in acute myeloid leukemia, which fuses the AML1 (RUNX1) and ETO (MTG8, RUNX1T1) genes. Previous studies have shown that AML1-ETO interferes with AML1 function but requires additional cooperating mutations to induce leukemia development. In mouse models, AML1-ETO forms lacking the C-terminus have been shown to have greatly enhanced leukemogenic potential. Here, we investigate the role of 2 AML1-ETO C-term ...[more]