Ontology highlight
ABSTRACT:
SUBMITTER: Ryu SW
PROVIDER: S-EPMC3643898 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ryu Seung-Wook SW Yoon Jonghee J Yim Nambin N Choi Kyungsun K Choi Chulhee C
PloS one 20130503 5
Transforming growth factor-β signaling is known to be a key signaling pathway in the induction of epithelial-mesenchymal transition. However, the mechanism of TGF-β signaling in the modulation of EMT remains unclear. In this study, we found that TGF-β treatment resulted in elongation of mitochondria accompanied by induction of N-cadherin, vimentin, and F-actin in retinal pigment epithelial cells. Moreover, OPA3, which plays a crucial role in mitochondrial dynamics, was downregulated following TG ...[more]