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ABSTRACT:
SUBMITTER: Okahashi N
PROVIDER: S-EPMC3643943 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Okahashi Nobuo N Nakata Masanobu M Sumitomo Tomoko T Terao Yutaka Y Kawabata Shigetada S
PloS one 20130503 5
Hydrogen peroxide (H2O2) produced by members of the mitis group of oral streptococci plays important roles in microbial communities such as oral biofilms. Although the cytotoxicity of H2O2 has been widely recognized, the effects of H2O2 produced by oral streptococci on host defense systems remain unknown. In the present study, we investigated the effect of H2O2 produced by Streptococcus oralis on human macrophage cell death. Infection by S. oralis was found to stimulate cell death of a THP-1 hum ...[more]