Ontology highlight
ABSTRACT:
SUBMITTER: Adinoff B
PROVIDER: S-EPMC3643993 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Adinoff Bryon B Devous Michael D MD Williams Mark J MJ Harris Thomas S TS Best Susan E SE Dong Hongyun H Zielinski Tanya T
Addiction biology 20120328 2
5-hydroxytryptamine 3 (5HT3) receptors are important modulators of mesostriatal dopaminergic transmission and have been implicated in the pathophysiology of cocaine reward, withdrawal and self-administration. In addition, the 5HT3 antagonist ondansetron is effective in treating early-onset, but not late-onset, alcohol-dependent subjects. To explore the role of 5HT3 receptor systems in cocaine addiction using functioning imaging, we administered ondansetron to 23 abstinent, treatment-seeking coca ...[more]