Ontology highlight
ABSTRACT:
SUBMITTER: Sengupta D
PROVIDER: S-EPMC3644118 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Sengupta Dola D Koblansky Alicia A Gaines Jennifer J Brown Tim T West A Phillip AP Zhang Dekai D Nishikawa Tak T Park Sung-Gyoo SG Roop R Martin RM Ghosh Sankar S
Journal of immunology (Baltimore, Md. : 1950) 20091214 2
Gram-negative bacteria belonging to the Brucella species cause chronic infections that can result in undulant fever, arthritis, and osteomyelitis in humans. Remarkably, Brucella sp. genomes encode a protein, named TcpB, that bears significant homology with mammalian Toll/IL-1 receptor domains and whose expression causes degradation of the phosphorylated, signal competent form of the adapter MyD88-adapter-like (MAL). This effect of TcpB is mediated through its box 1 region and has no effect on ot ...[more]