Sulfasalazine for brain cancer fits.
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ABSTRACT:
SUBMITTER: Sontheimer H
PROVIDER: S-EPMC3644176 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Sulfasalazine for brain cancer fits.
Sontheimer Harald H Bridges Richard J RJ
Expert opinion on investigational drugs 20120312 5
Recent research has identified an important role for a cystine-glutamate antiporter (system Xc) in the biology of malignant brain tumors. This transporter is effectively inhibited by sulfasalazine, a drug widely used to treat a number of chronic inflammatory conditions such as Crohn's disease. Preclinical data show that sulfasalazine is an effective inhibitor of tumor growth and tumor-associated seizures. These studies suggest that the cystine-glutamate antiporter is a valuable drug target for w ...[more]
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