Dataset Information

Multicenter comparison of PEG-IFN ?2a or ?2b plus ribavirin for treatment-naive HCV patient in Korean population.

ABSTRACT:

Background

Two recent Italian studies suggested that Pegylated-interferon (PEG-IFN) alfa-2a achieves a higher sustained virological response (SVR) rate than PEG-IFN alfa-2b. We intended to compare the efficacy and safety of PEG-IFN alfa-2a with those of PEG-IFN alfa-2b in Korean patients with chronic hepatitis C virus (HCV).

Methods

This retrospective, multi-center trial was conducted on 661 treatment-naïve chronic HCV patients. Patients received PEG-IFN alfa-2a (180 ?g/week; n=402) or PEG-IFN alfa-2b (1.5 ?g/kg/week; n=259) with ribavirin (800-1200 mg/day) for 24 or 48 weeks according to HCV genotypes.

Results

Early virologic response and sustained virologic response (SVR) rates were not significantly different between two PEG-IFN groups both in patients with HCV genotype 1 (all P-values>0.05) and 2/3 (all P-values>0.05). SVR rates were not different between two groups in each categorized baseline characteristics: age (years) (? 50 and >50), HCV viral load (IU/mL) (? 7 × 10(5) and >7 × 10(5)), and hepatic fibrosis (F0-2 and F3-4) (all P-values >0.05). In additional analysis for 480 patients who sufficiently complied with treatment doses and duration (80/80/80 rule) and propensity-score matched analysis, SVR rates were not different between two groups both in patients with HCV genotype 1 and 2/3 (all P-values >0.05). Adverse event rates were similar between two groups.

Conclusions

Unlike the Western data, efficacy and safety of PEG-IFN alfa-2a were similar to those of PEG-IFN alfa-2b in chronically HCV-infected Korean patients regardless of age, HCV viral load, and hepatic fibrosis.

SUBMITTER: Jin YJ

PROVIDER: S-EPMC3644280 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Multicenter comparison of PEG-IFN α2a or α2b plus ribavirin for treatment-naïve HCV patient in Korean population.

Jin Young-Joo YJ Lee Jin-Woo JW Lee Jung Il JI Park Sang Hoon SH Park Choong Kee CK Kim Young Seok YS Jeong Sook-Hyang SH Kim Yun Soo YS Kim Ju Hyun JH Hwang Seong Gyu SG Rim Kyu Sung KS Yim Hyung Joon HJ Cheong Jae Youn JY Cho Sung Won SW Lee June Sung JS Park Young Min YM Jang Jeong Won JW Lee Chun Kyon CK Sohn Joo Hyun JH Yang Jin Mo JM Han Seungbong S

BMC gastroenterology 20130429

<h4>Background</h4>Two recent Italian studies suggested that Pegylated-interferon (PEG-IFN) alfa-2a achieves a higher sustained virological response (SVR) rate than PEG-IFN alfa-2b. We intended to compare the efficacy and safety of PEG-IFN alfa-2a with those of PEG-IFN alfa-2b in Korean patients with chronic hepatitis C virus (HCV).<h4>Methods</h4>This retrospective, multi-center trial was conducted on 661 treatment-naïve chronic HCV patients. Patients received PEG-IFN alfa-2a (180 μg/week; n=40 ...[more]

PMID: 23627926

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