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Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.

ABSTRACT: Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation. As an approximately 30% to 50% reduction in KLF2 levels has been observed in human subjects with acute or chronic inflammatory disorders, we studied the biological response to inflammation in KLF2(+/-) mice. Herein, we show that partial deficiency of KLF2 modulates the in vivo response to acute (sepsis) and subacute (skin) inflammatory challenge. Mechanistically, we link the anti-inflammatory effects of KLF2 to the inhibition of NF-?B transcriptional activity. Collectively, the observations provide biologically relevant insights into KLF2-mediated modulation of these inflammatory processes that could potentially be manipulated for therapeutic gain.

SUBMITTER: Nayak L

PROVIDER: S-EPMC3644709 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.

Nayak Lalitha L Goduni Lediana L Takami Yoichi Y Sharma Nikunj N Kapil Parul P Jain Mukesh K MK Mahabeleshwar Ganapati H GH

The American journal of pathology 20130313 5

Although myeloid cell activation is requisite for an optimal innate immune response, this process must be tightly controlled to prevent collateral host tissue damage. Kruppel-like factor 2 (KLF2) is a potent regulator of myeloid cell proinflammatory activation. As an approximately 30% to 50% reduction in KLF2 levels has been observed in human subjects with acute or chronic inflammatory disorders, we studied the biological response to inflammation in KLF2(+/-) mice. Herein, we show that partial d ...[more]

PMID: 23499374

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