Ontology highlight
ABSTRACT:
SUBMITTER: Finkelshtein D
PROVIDER: S-EPMC3645523 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Finkelshtein Danit D Werman Ariel A Novick Daniela D Barak Sara S Rubinstein Menachem M
Proceedings of the National Academy of Sciences of the United States of America 20130415 18
Vesicular stomatitis virus (VSV) exhibits a remarkably robust and pantropic infectivity, mediated by its coat protein, VSV-G. Using this property, recombinant forms of VSV and VSV-G-pseudotyped viral vectors are being developed for gene therapy, vaccination, and viral oncolysis and are extensively used for gene transduction in vivo and in vitro. The broad tropism of VSV suggests that it enters cells through a highly ubiquitous receptor, whose identity has so far remained elusive. Here we show th ...[more]