Ontology highlight
ABSTRACT:
SUBMITTER: Zietara N
PROVIDER: S-EPMC3645533 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Ziętara Natalia N Łyszkiewicz Marcin M Witzlau Katrin K Naumann Ronald R Hurwitz Robert R Langemeier Jörg J Bohne Jens J Sandrock Inga I Ballmaier Matthias M Weiss Siegfried S Prinz Immo I Krueger Andreas A
Proceedings of the National Academy of Sciences of the United States of America 20130415 18
T-cell receptor (TCR) signal strength determines selection and lineage fate at the CD4(+)CD8(+) double-positive stage of intrathymic T-cell development. Members of the miR-181 family constitute the most abundantly expressed microRNA at this stage of T-cell development. Here we show that deletion of miR-181a/b-1 reduced the responsiveness of double-positive thymocytes to TCR signals and virtually abrogated early invariant natural killer T (iNKT) cell development, resulting in a dramatic reduction ...[more]