Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.
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ABSTRACT:
SUBMITTER: Ala U
PROVIDER: S-EPMC3645534 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.
Ala Ugo U Karreth Florian A FA Bosia Carla C Pagnani Andrea A Taulli Riccardo R Léopold Valentine V Tay Yvonne Y Provero Paolo P Zecchina Riccardo R Pandolfi Pier Paolo PP
Proceedings of the National Academy of Sciences of the United States of America 20130327 18
Competitive endogenous (ce)RNAs cross-regulate each other through sequestration of shared microRNAs and form complex regulatory networks based on their microRNA signature. However, the molecular requirements for ceRNA cross-regulation and the extent of ceRNA networks remain unknown. Here, we present a mathematical mass-action model to determine the optimal conditions for ceRNA activity in silico. This model was validated using phosphatase and tensin homolog (PTEN) and its ceRNA VAMP (vesicle-ass ...[more]
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