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Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.


ABSTRACT: This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude with a discussion of the poorly defined mechanisms that mediate the long-term maintenance of IDO-expression in response to inflammatory stimuli and how selective modulation of IDO activity may be used in the treatment of disease.

SUBMITTER: Harden JL 

PROVIDER: S-EPMC3645912 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.

Harden Jamie L JL   Egilmez Nejat K NK  

Immunological investigations 20120101 6-7


This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude with a discussion of the poorly defined mechanisms that mediate the long-term maint  ...[more]

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