Ontology highlight
ABSTRACT:
SUBMITTER: Musselman CA
PROVIDER: S-EPMC3645987 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Musselman Catherine A CA Lalonde Marie-Eve ME Côté Jacques J Kutateladze Tatiana G TG
Nature structural & molecular biology 20121201 12
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for regulating chromatin structure and dynamics. PTMs can alter direct interactions between histones and DNA and serve as docking sites for protein effectors, or readers, of these PTMs. Binding of the readers recruits or stabilizes various components of the nuclear signaling machinery at specific genomic sites, mediating fundamental DNA-templated processes, including gene transcription and DNA recombination, repli ...[more]