Ontology highlight
ABSTRACT:
SUBMITTER: Pichiorri F
PROVIDER: S-EPMC3646490 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20130422 5
Numerous studies have described the altered expression and the causal role of microRNAs (miRNAs) in human cancer. However, to date, efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here we find that nucleolin (NCL), a major nucleolar protein, posttranscriptionally regulates the expression of a specific subset of miRNAs, including miR-21, miR-221, miR-222, and miR-103, that are causally involved in breast cancer initiation, progression, and drug resist ...[more]