Ontology highlight
ABSTRACT:
SUBMITTER: Henry NL
PROVIDER: S-EPMC3646626 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Henry N Lynn NL Skaar Todd C TC Dantzer Jessica J Li Lang L Kidwell Kelley K Gersch Christina C Nguyen Anne T AT Rae James M JM Desta Zeruesenay Z Oesterreich Steffi S Philips Santosh S Carpenter Janet S JS Storniolo Anna M AM Stearns Vered V Hayes Daniel F DF Flockhart David A DA
Breast cancer research and treatment 20130402 3
Up to 25 % of patients discontinue adjuvant aromatase inhibitor (AI) therapy due to intolerable symptoms. Predictors of which patients will be unable to tolerate these medications have not been defined. We hypothesized that inherited variants in candidate genes are associated with treatment discontinuation because of AI-associated toxicity. We prospectively evaluated reasons for treatment discontinuation in women with hormone receptor-positive breast cancer initiating adjuvant AI through a multi ...[more]