Ontology highlight
ABSTRACT:
SUBMITTER: Rasche L
PROVIDER: S-EPMC3646784 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Rasche Leo L Duell Johannes J Morgner Charlotte C Chatterjee Manik M Hensel Frank F Rosenwald Andreas A Einsele Hermann H Topp Max S MS Brändlein Stephanie S
PloS one 20130507 5
In contrast to other haematological malignancies, targeted immunotherapy has not entered standard treatment regimens for de novo or relapsed multiple myeloma (MM) yet. While a number of IgG-formatted monoclonal antibodies are currently being evaluated in clinical trials in MM, our study aimed to investigate whether the fully human IgM monoclonal antibody PAT-SM6 that targets a tumour-specific variant of the heat shock protein GRP78 might be an attractive candidate for future immunotherapeutic ap ...[more]