Ontology highlight
ABSTRACT:
SUBMITTER: Takasugi N
PROVIDER: S-EPMC3646787 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Takasugi Nobumasa N Sasaki Tomoki T Ebinuma Ihori I Osawa Satoko S Isshiki Hayato H Takeo Koji K Tomita Taisuke T Iwatsubo Takeshi T
PloS one 20130507 5
Sphingosine-1-phosphate (S1P) is a pluripotent lipophilic mediator working as a ligand for G-protein coupled S1P receptors (S1PR), which is currently highlighted as a therapeutic target for autoimmune diseases including relapsing forms of multiple sclerosis. Sphingosine related compounds, FTY720 and KRP203 known as S1PR modulators, are phosphorylated by sphingosine kinase 2 (SphK2) to yield the active metabolites FTY720-P and KRP203-P, which work as functional antagonists for S1PRs. Here we repo ...[more]