Ontology highlight
ABSTRACT:
SUBMITTER: Rideout MC
PROVIDER: S-EPMC3646928 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Rideout Marc C MC Naili Ilham I Boldt Jeffrey L JL Flores-Fujimoto America A Patra Sukanya S Rostron Jason E JE Segall Anca M AM
Peptides 20130103
DNA repair pathways in bacteria that use homologous recombination involve the formation and subsequent resolution of Holliday junction (HJ) intermediates. We have previously identified several hexameric peptides that bind to HJs and interfere with HJ processing enzymes in vitro. The peptide WRWYCR and its D-amino acid stereoisomer wrwycr, are potent antibacterial agents. These hexapeptides must form homodimers in order to interact stably with HJs, and inhibit bacterial growth, and this represent ...[more]