Ontology highlight
ABSTRACT:
SUBMITTER: Beste C
PROVIDER: S-EPMC3647202 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Beste Christian C Stock Ann-Kathrin AK Ness Vanessa V Hoffmann Rainer R Lukas Carsten C Saft Carsten C
Scientific reports 20130101
In several neurodegenerative diseases, like Huntington's disease (HD), treatments are still lacking. To determine whether a treatment is effective, sensitive disease progression biomarkers are especially needed for the premanifest phase, since this allows the evaluation of neuroprotective treatments preventing, or delaying disease manifestation. On the basis of a longitudinal study we present a biomarker that was derived by integrating behavioural and neurophysiological data reflecting cognitive ...[more]