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Genome-wide association study of personality traits in the long life family study.


ABSTRACT: Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect LD, associated with agreeableness reached genome-wide significance (p?

SUBMITTER: Bae HT 

PROVIDER: S-EPMC3647245 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Genome-wide association study of personality traits in the long life family study.

Bae Harold T HT   Sebastiani Paola P   Sun Jenny X JX   Andersen Stacy L SL   Daw E Warwick EW   Terracciano Antonio A   Ferrucci Luigi L   Perls Thomas T TT  

Frontiers in genetics 20130508


Personality traits have been shown to be associated with longevity and healthy aging. In order to discover novel genetic modifiers associated with personality traits as related with longevity, we performed a genome-wide association study (GWAS) on personality factors assessed by NEO-five-factor inventory in individuals enrolled in the Long Life Family Study (LLFS), a study of 583 families (N up to 4595) with clustering for longevity in the United States and Denmark. Three SNPs, in almost perfect  ...[more]

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