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The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex.


ABSTRACT: Although adult vertebrates sense changes in head position by using two classes of accelerometer, at larval stages zebrafish lack functional semicircular canals and rely exclusively on their otolithic organs to transduce vestibular information.Despite this limitation, we find that larval zebrafish perform an effective vestibulo-ocular reflex (VOR) that serves to stabilize gaze in response to pitch and roll tilts. By using single-cell electroporations and targeted laser ablations, we identified a specific class of central vestibular neurons, located in the tangential nucleus, that are essential for the utricle-dependent VOR. Tangential nucleus neurons project contralaterally to extraocular motoneurons and in addition to multiple sites within the reticulospinal complex.We propose that tangential neurons function as a broadband inertial accelerometer, processing utricular acceleration signals to control the activity of extraocular and postural neurons, thus completing a fundamental three-neuron circuit responsible for gaze stabilization.

SUBMITTER: Bianco IH 

PROVIDER: S-EPMC3647252 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex.

Bianco Isaac H IH   Ma Leung-Hang LH   Schoppik David D   Robson Drew N DN   Orger Michael B MB   Beck James C JC   Li Jennifer M JM   Schier Alexander F AF   Engert Florian F   Baker Robert R  

Current biology : CB 20120614 14


<h4>Background</h4>Although adult vertebrates sense changes in head position by using two classes of accelerometer, at larval stages zebrafish lack functional semicircular canals and rely exclusively on their otolithic organs to transduce vestibular information.<h4>Results</h4>Despite this limitation, we find that larval zebrafish perform an effective vestibulo-ocular reflex (VOR) that serves to stabilize gaze in response to pitch and roll tilts. By using single-cell electroporations and targete  ...[more]

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