Ontology highlight
ABSTRACT:
SUBMITTER: Hatle KM
PROVIDER: S-EPMC3648061 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Hatle Ketki M KM Gummadidala Phani P Navasa Nicolás N Bernardo Edgar E Dodge John J Silverstrim Brian B Fortner Karen K Burg Elianne E Suratt Benajamin T BT Hammer Juergen J Radermacher Michael M Taatjes Douglas J DJ Thornton Tina T Anguita Juan J Rincon Mercedes M
Molecular and cellular biology 20130325 11
Mitochondria are the main engine that generates ATP through oxidative phosphorylation within the respiratory chain. Mitochondrial respiration is regulated according to the metabolic needs of cells and can be modulated in response to metabolic changes. Little is known about the mechanisms that regulate this process. Here, we identify MCJ/DnaJC15 as a distinct cochaperone that localizes at the mitochondrial inner membrane, where it interacts preferentially with complex I of the electron transfer c ...[more]