Ontology highlight
ABSTRACT:
SUBMITTER: Rubio RM
PROVIDER: S-EPMC3648104 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Rubio Rosa M RM Mora Silvia I SI Romero Pedro P Arias Carlos F CF López Susana S
Journal of virology 20130327 11
Rotaviruses are the most important agent of severe gastroenteritis in young children. Early in infection, these viruses take over the host translation machinery, causing a severe shutoff of cell protein synthesis while viral proteins are efficiently synthesized. In infected cells, there is an accumulation of the cytoplasmic poly(A)-binding protein in the nucleus, induced by the viral protein NSP3. Here we found that poly(A)-containing mRNAs also accumulate and become hyperadenylated in the nucle ...[more]