Cellular adaptations of dorsal raphe serotonin neurons associated with the development of active coping in response to social stress.

ABSTRACT:

Background

Social stress is a risk factor for affective disorders for certain vulnerable individuals. Stress and depression are linked in part through regulation of the dorsal raphe (DR)-serotonin (5-HT) system by the stress-related neuropeptide, corticotropin-releasing factor (CRF). We used a rat social stress model that shows individual differences in coping strategies to determine whether differences in CRF-5-HT interactions underlie individual differences in the vulnerability to social stress.

Methods

Rats were exposed to the resident-intruder model of social stress for 5 days. In vivo single-unit recordings assessed DR-5-HT neuronal responses to CRF and immunoelectron microscopy assessed CRF1 and CRF2 cellular localization 24 hours after the last stress.

Results

SUBMITTER: Wood SK 

PROVIDER: S-EPMC3648616 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature