Hazard ratio estimation for biomarker-calibrated dietary exposures.

ABSTRACT: Uncertainty concerning the measurement error properties of self-reported diet has important implications for the reliability of nutritional epidemiology reports. Biomarkers based on the urinary recovery of expended nutrients can provide an objective measure of short-term nutrient consumption for certain nutrients and, when applied to a subset of a study cohort, can be used to calibrate corresponding self-report nutrient consumption assessments. A nonstandard measurement error model that makes provision for systematic error and subject-specific error, along with the usual independent random error, is needed for the self-report data. Three estimation procedures for hazard ratio (Cox model) parameters are extended for application to this more complex measurement error structure. These procedu

SUBMITTER: Shaw PA 

PROVIDER: S-EPMC3648661 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature