Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity.
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ABSTRACT:
SUBMITTER: Leopold JA
PROVIDER: S-EPMC3648863 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Publications
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity.
Leopold Jane A JA Dam Aamir A Maron Bradley A BA Scribner Anne W AW Liao Ronglih R Handy Diane E DE Stanton Robert C RC Pitt Bertram B Loscalzo Joseph J
Nature medicine 20070204 2
Hyperaldosteronism is associated with impaired vascular reactivity; however, the mechanisms by which aldosterone promotes endothelial dysfunction remain unknown. Glucose-6-phosphate dehydrogenase (G6PD) modulates vascular function by limiting oxidant stress to preserve bioavailable nitric oxide (NO(*)). Here we show that aldosterone (10(-9)-;10(-7) mol/l) decreased endothelial G6PD expression and activity in vitro, resulting in increased oxidant stress and decreased NO(*) levels-similar to what ...[more]
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