Ontology highlight
ABSTRACT:
SUBMITTER: Gurtan AM
PROVIDER: S-EPMC3650230 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Genes & development 20130401 8
MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to derepression of let-7 targets at levels that exceed 10-fold to 100-fold with increases in transcription. Direct and indirect targets of this miRNA belong to a mid-gestation embryonic program that encompasses known oncofetal genes as well as oncogenes not previously associate ...[more]