Ontology highlight
ABSTRACT:
SUBMITTER: Koytiger G
PROVIDER: S-EPMC3650332 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Koytiger Grigoriy G Kaushansky Alexis A Gordus Andrew A Rush John J Sorger Peter K PK MacBeath Gavin G
Molecular & cellular proteomics : MCP 20130128 5
Mutation and overexpression of receptor tyrosine kinases or the proteins they regulate serve as oncogenic drivers in diverse cancers. To better understand receptor tyrosine kinase signaling and its link to oncogenesis, we used protein microarrays to systematically and quantitatively measure interactions between virtually every SH2 or PTB domain encoded in the human genome and all known sites of tyrosine phosphorylation on 40 receptor tyrosine kinases and on most of the SH2 and PTB domain-contain ...[more]