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Biosynthesis of the iron-molybdenum cofactor of nitrogenase.

ABSTRACT: The iron-molybdenum cofactor (the M-cluster) serves as the active site of molybdenum nitrogenase. Arguably one of the most complex metal cofactors in biological systems, the M-cluster is assembled through the formation of an 8Fe core prior to the insertion of molybdenum and homocitrate into this core. Here, we review the recent progress in the research area of M-cluster assembly, with an emphasis on our work that provides useful insights into the mechanistic details of this process.

SUBMITTER: Hu Y

PROVIDER: S-EPMC3650356 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Biosynthesis of the iron-molybdenum cofactor of nitrogenase.

Hu Yilin Y Ribbe Markus W MW

The Journal of biological chemistry 20130328 19

The iron-molybdenum cofactor (the M-cluster) serves as the active site of molybdenum nitrogenase. Arguably one of the most complex metal cofactors in biological systems, the M-cluster is assembled through the formation of an 8Fe core prior to the insertion of molybdenum and homocitrate into this core. Here, we review the recent progress in the research area of M-cluster assembly, with an emphasis on our work that provides useful insights into the mechanistic details of this process. ...[more]

PMID: 23539617

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