Biosynthesis of the urease metallocenter.
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ABSTRACT:
SUBMITTER: Farrugia MA
PROVIDER: S-EPMC3650357 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Biosynthesis of the urease metallocenter.
Farrugia Mark A MA Macomber Lee L Hausinger Robert P RP
The Journal of biological chemistry 20130328 19
Metalloenzymes often require elaborate metallocenter assembly systems to create functional active sites. The medically important dinuclear nickel enzyme urease provides an excellent model for studying metallocenter assembly. Nickel is inserted into the urease active site in a GTP-dependent process with the assistance of UreD/UreH, UreE, UreF, and UreG. These accessory proteins orchestrate apoprotein activation by delivering the appropriate metal, facilitating protein conformational changes, and ...[more]
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