Ontology highlight
ABSTRACT:
SUBMITTER: Cao Y
PROVIDER: S-EPMC3651420 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Cao Yang Y Chtarbanova Stanislava S Petersen Andrew J AJ Ganetzky Barry B
Proceedings of the National Academy of Sciences of the United States of America 20130423 19
A growing body of evidence in humans implicates chronic activation of the innate immune response in the brain as a major cause of neuropathology in various neurodegenerative conditions, although the mechanisms remain unclear. In an unbiased genetic screen for mutants exhibiting neurodegeneration in Drosophila, we have recovered a mutation of dnr1 (defense repressor 1), a negative regulator of the Imd (immune deficiency) innate immune-response pathway. dnr1 mutants exhibit shortened lifespan and ...[more]