Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.
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ABSTRACT:
SUBMITTER: Hato T
PROVIDER: S-EPMC3651626 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
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Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity.
Hato Takashi T El-Achkar Tarek M TM Dagher Pierre C PC
American journal of physiology. Renal physiology 20130320 10
The importance of innate immunity for survival is underscored by its presence at almost every level of the evolutionary tree of life. The task of "danger" recognition by the innate immune system is carried out by a broad class of pattern recognition receptors. These receptors are expressed in both hematopoietic and nonhematopoietic cells such as renal epithelial cells. Upon activation, pattern recognition receptors induce essentially two types of defensive responses: inflammation and phagocytosi ...[more]
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