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Selective RNA versus DNA G-quadruplex targeting by in?situ click chemistry.

ABSTRACT: It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.

SUBMITTER: Di Antonio M 

PROVIDER: S-EPMC3652031 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Selective RNA versus DNA G-quadruplex targeting by in situ click chemistry.

Di Antonio Marco M   Biffi Giulia G   Mariani Angelica A   Raiber Eun-Ang EA   Rodriguez Raphaël R   Balasubramanian Shankar S  

Angewandte Chemie (International ed. in English) 20121004 44

It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA. ...[more]

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