Ontology highlight
ABSTRACT:
SUBMITTER: Park D
PROVIDER: S-EPMC3652251 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Park Dongsu D Spencer Joel A JA Koh Bong Ihn BI Kobayashi Tatsuya T Fujisaki Joji J Clemens Thomas L TL Lin Charles P CP Kronenberg Henry M HM Scadden David T DT
Cell stem cell 20120301 3
Mesenchymal stem cells (MSCs) commonly defined by in vitro functions have entered clinical application despite little definition of their function in residence. Here, we report genetic pulse-chase experiments that define osteoblastic cells as short-lived and nonreplicative, requiring replenishment from bone-marrow-derived, Mx1(+) stromal cells with "MSC" features. These cells respond to tissue stress and migrate to sites of injury, supplying new osteoblasts during fracture healing. Single cell t ...[more]