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Ternary resin-bound Dynamic Combinatorial Chemistry.

ABSTRACT: The ability to carry out simultaneous orthogonal exchange chemistries has opened new opportunities for increasing the numerical and structural diversity accessible to Dynamic Combinatorial Chemistry. We present proof-of-concept experiments demonstrating this concept is transferrable to resin-bound DCC, facilitating the generation and analysis of libraries with greater structural diversity.

SUBMITTER: Gromova AV 

PROVIDER: S-EPMC3652255 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Ternary resin-bound Dynamic Combinatorial Chemistry.

Gromova Anna V AV   Ciszewski Joseph M JM   Miller Benjamin L BL  

Chemical communications (Cambridge, England) 20120113 15

The ability to carry out simultaneous orthogonal exchange chemistries has opened new opportunities for increasing the numerical and structural diversity accessible to Dynamic Combinatorial Chemistry. We present proof-of-concept experiments demonstrating this concept is transferrable to resin-bound DCC, facilitating the generation and analysis of libraries with greater structural diversity. ...[more]

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