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Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.


ABSTRACT: The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4(KMT1). This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome segregation. In the absence of heterochromatin, cells show an increased rate of recombination in the centromere, as well as chromosome loss. These defects are severely aggravated by loss of replication fork stability. Thus, heterochromatin proteins and replication fork protection mechanisms work in concert to prevent abnormal recombination, preserve centromere integrity, and ensure faithful chromosome segregation.

SUBMITTER: Li PC 

PROVIDER: S-EPMC3652564 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.

Li Pao-Chen PC   Petreaca Ruben C RC   Jensen Amanda A   Yuan Ji-Ping JP   Green Marc D MD   Forsburg Susan L SL  

Cell reports 20130307 3


The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4(KMT1). This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome segregation. In the absence of heterochromatin, cells show an increased rate of recombination in the centromere, as well as chromosome loss. These defects are severely aggravated by loss of replication fork stability. Thus, heterochromatin prot  ...[more]

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