Ontology highlight
ABSTRACT:
SUBMITTER: Li PC
PROVIDER: S-EPMC3652564 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Li Pao-Chen PC Petreaca Ruben C RC Jensen Amanda A Yuan Ji-Ping JP Green Marc D MD Forsburg Susan L SL
Cell reports 20130307 3
The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4(KMT1). This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome segregation. In the absence of heterochromatin, cells show an increased rate of recombination in the centromere, as well as chromosome loss. These defects are severely aggravated by loss of replication fork stability. Thus, heterochromatin prot ...[more]