Ontology highlight
ABSTRACT:
SUBMITTER: Conrad C
PROVIDER: S-EPMC3652570 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Conrad Curdin C Gregorio Josh J Wang Yi-Hong YH Ito Tomoki T Meller Stephan S Hanabuchi Shino S Anderson Sonya S Atkinson Neely N Ramirez Pedro T PT Liu Yong-Jun YJ Freedman Ralph R Gilliet Michel M
Cancer research 20120731 20
Epithelial ovarian cancer (EOC) is the fifth most common cause of cancer death among women. Despite its immunogenicity, effective antitumor responses are limited, due, in part, to the presence of forkhead box protein 3-positive (Foxp3(+)) T regulatory (Treg) cells in the tumor microenvironment. However, the mechanisms that regulate the accumulation and the suppressive function of these Foxp3(+) Treg cells are poorly understood. Here, we found that the majority of Foxp3(+) Treg cells accumulating ...[more]