Ontology highlight
ABSTRACT:
SUBMITTER: Hung T
PROVIDER: S-EPMC3652667 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Nature genetics 20110605 7
Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known. Here we use an ultrahigh-density array that tiles the promoters of 56 cell-cycle genes to interrogate 108 samples representing diverse perturbations. We identify 216 transcribed regions that encode putative lncRNAs, many with RT-PCR-validated periodic expression during the cell cycle, show altered ex ...[more]