Ontology highlight
ABSTRACT:
SUBMITTER: Saitoh M
PROVIDER: S-EPMC3652834 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130513 5
Bone morphogenetic proteins (BMPs) regulate various biological processes, mostly mediated by cells of mesenchymal origin. However, the roles of BMPs in epithelial cells are poorly understood. Here, we demonstrate that, in polarized epithelial cells, BMP signals are transmitted from BMP receptor complexes exclusively localized at the basolateral surface of the cell membrane. In addition, basolateral stimulation with BMP increased expression of components of tight junctions and enhanced the transe ...[more]