The NuRD architecture.
Ontology highlight
ABSTRACT:
SUBMITTER: Allen HF
PROVIDER: S-EPMC3652912 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
The NuRD architecture.
Allen Hillary F HF Wade Paul A PA Kutateladze Tatiana G TG
Cellular and molecular life sciences : CMLS 20130123 19
The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin organization, gene transcription, genomic stability and developmental signaling. NuRD has a unique dual enzymatic activity, containing an ATPase and a histone deacetylase among its six core subunits. Recent studies indicate that NuRD composition and the interplay between subunits may dictate the diverse functions of the complex. In this review, we examine the structures and biological roles of the NuRD subunits and disc ...[more]
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