Ontology highlight
ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC3653410 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Tang Hao H Brennan Jennifer J Karl Jeannie J Hamada Yoshio Y Raetzman Lori L Capel Blanche B
Development (Cambridge, England) 20081016 22
During testis development, fetal Leydig cells increase their population from a pool of progenitor cells rather than from proliferation of a differentiated cell population. However, the mechanism that regulates Leydig stem cell self-renewal and differentiation is unknown. Here, we show that blocking Notch signaling, by inhibiting gamma-secretase activity or deleting the downstream target gene Hairy/Enhancer-of-split 1, results in an increase in Leydig cells in the testis. By contrast, constitutiv ...[more]