Ontology highlight
ABSTRACT:
SUBMITTER: Le X
PROVIDER: S-EPMC3653557 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Le Xiuning X Pugach Emily K EK Hettmer Simone S Storer Narie Y NY Liu Jianing J Wills Airon A AA DiBiase Antony A Chen Eleanor Y EY Ignatius Myron S MS Poss Kenneth D KD Wagers Amy J AJ Langenau David M DM Zon Leonard I LI
Development (Cambridge, England) 20130424 11
The zebrafish is a powerful genetic model that has only recently been used to dissect developmental pathways involved in oncogenesis. We hypothesized that operative pathways during embryogenesis would also be used for oncogenesis. In an effort to define RAS target genes during embryogenesis, gene expression was evaluated in Tg(hsp70-HRAS(G12V)) zebrafish embryos subjected to heat shock. dusp6 was activated by RAS, and this was used as the basis for a chemical genetic screen to identify small mol ...[more]