Ontology highlight
ABSTRACT:
SUBMITTER: Nassiri M
PROVIDER: S-EPMC3653838 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Nassiri Marjan M Liu Ju J Kulak Stephen S Uwiera Richard R E RR Aird William C WC Ballermann Barbara J BJ Jahroudi Nadia N
Arteriosclerosis, thrombosis, and vascular biology 20100429 7
<h4>Objective</h4>To determine the role of repressors in cell type and organ-specific activation of von Willebrand factor (VWF) promoter sequences -487 to 247 in vivo.<h4>Methods and results</h4>Activation patterns of wild-type and mutant VWF promoters (sequences -487 to 247) containing mutations in repressors nuclear factor-I (NFI)- and nuclear factor Y (NFY)-binding sites were analyzed in transgenic mice. Mutation of the NFI-binding site activated the promoter in heart and lung endothelial cel ...[more]