Ontology highlight
ABSTRACT:
SUBMITTER: Heinberg A
PROVIDER: S-EPMC3654098 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Heinberg Adina A Siu Edwin E Stern Chaya C Lawrence Elizabeth A EA Ferdig Michael T MT Deitsch Kirk W KW Kirkman Laura A LA
Molecular microbiology 20130424 4
Resistance to antimalarials targeting the folate pathway is widespread. GTP-cyclohydrolase (gch1), the first enzyme in this pathway, exhibits extensive copy number variation (CN) in parasite isolates from areas with a history of longstanding antifolate use. Increased CN of gch1 is associated with a greater number of point mutations in enzymes targeted by the antifolates, pyrimethamine and sulphadoxine. While these observations suggest that increases in gch1 CN are an adaptation to drug pressure, ...[more]