Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki T
PROVIDER: S-EPMC3654099 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Suzuki Tsukasa T Bridges Dave D Nakada Daisuke D Skiniotis Georgios G Morrison Sean J SJ Lin Jiandie D JD Saltiel Alan R AR Inoki Ken K
Molecular cell 20130425 3
AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by inhibiting anabolic and activating catabolic processes. While AMPK activation has been extensively studied, mechanisms that inhibit AMPK remain elusive. Here we report that glycogen synthase kinase 3 (GSK3) inhibits AMPK function. GSK3 forms a stable complex with AMPK through interactions with the AMPK β regulatory subunit and phosphorylates the AMPK α catalytic subunit. This phosphorylation enhances the accessibility o ...[more]