The current approach to initial crystallization screening of proteins is under-sampled.
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ABSTRACT:
SUBMITTER: Gorrec F
PROVIDER: S-EPMC3654315 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
The current approach to initial crystallization screening of proteins is under-sampled.
Journal of applied crystallography 20130418 Pt 3
Protein crystallization conditions that resulted in crystal structures published by scientists at the MRC Laboratory of Molecular Biology (MRC-LMB, Cambridge, UK) have been analysed. It was observed that the more often a crystallization reagent had been used to formulate the initial conditions, the more often it was found in the reported conditions that yielded diffraction quality crystals. The present analysis shows that, despite the broad variety of reagents, they have the same impact overall ...[more]
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